Journal of Rare Cardiovascular Diseases

Heyde’s syndrome is defined as a combination of gastrointestinal bleeding from a gastrointestinal angiodysplasia in patients with aortic stenosis. An acquired von Willebrand factor deficiency secondary to aortic stenosis is considered to be the major abnormality in Heyde’s syndrome. Management of Heyde’s syndrome requires cooperation of many different kinds of specialists: cardiologists, gastroenterologists, hematologists, general surgeons and cardiosurgeon. We present a care report of 62 years old female with no history of cardiovascular disorders referred to the Centre of Rare Cardiovascular Diseases in Kraków for cardiological evaluation of a heart murmur prior to a surgical procedure of a vascular malformation in colon. JRCD 2014; 1 (7): 17–20

Heyde’s syndrome, gastrointestinal bleeding, aortic stenosis, acquired von Willebrand factor deficiency

Heyde EC. Gastrointestinal bleeding in aortic stenosis. N Engl J Med 1958; 259: 196.

Olearchyk AS. Heyde’s syndrome. J Thorac Cardiovasc Surg 1992; 103: 823–824.

King RM, Pluth JR, Giuliani ER. The association of unexplained gastrointestinal bleeding with calcific aortic stenosis. Ann Thorac Surg 1987; 44: 514–516.

Warkentin TE, Moore JC, Morgan DG. Aortic stenosis and bleeding gastrointestinal angiodysplasia: is acquired von Willebrand’s disease the link? Lancet 1992; 340: 35–37.

Islam S, Islam E, Cevik C, et al. Aortic stenosis and angiodysplastic gastrointestinal bleeding: Heyde’s disease. Heart Lung 2012; 41: 90–94.

Loscalzo J. From Clinical Observation to Mechanism – Heyde’s Syndrome. N Engl J Med 2012; 367: 1954–1956.

Abi-Akar R, El-Rassi I, Karam N, et al. Treatment of Heyde’s Syndrome by Aortic Valve Replacement. Curr Cardiol Rev 2011; 7: 47–49.

Figuinha FC, Spina GS, Tarasoutchi F. Heyde’s syndrome: case report and literature review. Arq Bras Cardiol 2011; 96: e42–45.