Background: Interstitial Pneumonia with Autoimmune Features (IPAF) is a subcategory of interstitial lung disease (ILD) with autoimmune characteristic, but not meeting any criteria of a specific connective tissue disease (CTD). Little Indian data on the prevalence and determinants of IPAF exist. This paper seeks to determine the epidemiology and possible risk factors of IPAF in a South Indian tertiary care hospital. Aim and Objectives: To establish the prevalence of IPAF in the ILD patients, to define the possible risk factors, and to identify the correlation between clinical variables and IPAF. Methods: The cross-sectional analytical cross-sectional study aimed to be done in the Department of General Medicine, Sree Balaji Medical College & Hospital, Chennai, between July 2023 and January 2025. A total of 50 patients with ILD were selected and assessed by the ERS/ATS 2015 criteria. Data was collected in the form of clinical history, serological examination and HRCT chest results. The analysis was conducted by the use of open Epi 3.0 Chi-square test was used and p was set at 0.05. Findings: The average age of the participants was 54.04 years of age with a standard deviation of 10.15 years (35 years to 75 years old). The majority of respondents (64%) had the age of 41 years to 60. 34% of the patients had a history of COVID-19 infection. The rates were 32 and 34 percent respectively with diabetes mellitus and hypothyroidism. Nonetheless, such independent variables as age, gender, previous COVID infection, diabetes, hypothyroidism did not significantly influence the presence of IPAF (p > 0.05). Conclusion: IPAF is also found between ILD patients in the tertiary care cohort, but other common comorbidities of the system and previous infections were not significantly associated. These facts indicate that the IPAF can occur without the conventional systemic risk factors, and it is necessary to conduct specific clinical, serological, and radiological examination to make an accurate diagnosis.