The present study was designed to examine the preventive and therapeutic effects of the hot aqueous extract of jujube fruit on liver histological changes of albino male rats administered the hot aqueous extract of jujube fruit, dexamethasone and risedronate sodium. The experiment was carried out inside the animal house of the College of Science, University of Kufa, starting from the start of July 2024 till the end of April 2025. This experiment used 30 male rats (9-11) weeks old with a weight of (200-250) grams. They were divided into 6 groups (5 rats per group) Experimental Details: The experiment was conducted over a period of 30-days. The first cohort served as the control cohort and received no treatment except for food and water. A second group received a dose of the antinflammatory dexamethasone of 0.05 mg/kg of body weight. The 3rd group received risedronate sodium (5 mg/kg) daily by way of oral administration. The fourth group was administered a daily aqueous extract of jujube plant as 3000 mg/kg, The fifth group was dosed with 0.05 mg/kg of body weight dexamethasone and subsequently a daily oral dose of risedronate sodium as 5 mg/kg. The sixth group was administered jujube plant aqueous extract at a concentration of 3000 mg/kg orally daily and after one hour, 0.05 mg/kg oral dexamethasone and considered as preventive group, the seventh group received orally 0.05 mg/kg daily dexamethasone one hour after, was dosed with 3000 mg/kg of the aqueous extract of the jujube plant and was assigned to treatment group. The livers were harvested post-mortem for histological analyses In the current study, the results of the histological examination of the liver of male rats in the control group proved that the tissue composition of the liver was normal and no pathological changes were observed in it, while the histological sections of the liver of rats treated with dexamethasone at a dose of (0.05) mg/kg of body weight and those treated with risedronate sodium at a dose of (5) mg/kg of body weight and group treated with dexamethasone at a dose of (0.05) mg/kg of body weight + risedronate sodium at a dose of (5) mg/kg of body weight for (30) days showed histopathological effects were represented by calcification and necrosis of hepatic cells, dilatation of sinusoids, infiltration of inflammatory cells, destruction of the hepatic vein wall, atrophy of the hepatic vein and separation of the hepatic vein from its base compared to the control group against which showed histopathological composition of the liver wild rats that was normal or close to normal. In the group that received dexamethasone with risedronate sodium for 30 days (dexamethasone 0.05 mg/kg + risedronate sodium 5 mg/kg) and the group treated similarly with hot aqueous extract of jujube plant (3000 mg/kg) + dexamethasone (0.05 mg/kg) for 30 days; The group treated with dexamethasone + hot aqueous extract of jujube plant (3000 mg/kg) was only observed detachment of lining the hepatic vein compared to the control group for 30 days (Fig. 2). In conclusion: We think calcareous extract of the jujube herb can workaround to prevent and cure adverse histopathological effects on liver tissue induced by administration of dexamethasone and risedronate sodium.