Journal of Rare Cardiovascular Diseases

ISSN: 2299-3711 (Print) e-ISSN: 2300-5505 (Online)

Atrial Fibrillation Management: The Combined Approach of Left Atrial Appendage Closure and Catheter Ablation

John Alex

Full Text:

PDF

Abstract

Atrial fibrillation (AF) is a prevalent cardiac arrhythmia associated with significant thromboembolic and bleeding risks. The combined procedure of left atrial appendage closure (LAAC) and catheter ablation has emerged as an innovative approach to address these dual challenges, particularly in high-risk patients. This review explores the evolution of LAAC, highlights clinical evidence supporting its integration with catheter ablation, and discusses technological advancements shaping its future. Studies demonstrate that the combined procedure significantly reduces stroke and bleeding risks, achieves high procedural success rates, and ensures effective arrhythmia control. Real-world data further validate its safety and efficacy, particularly in specialized centers. Despite its promise, challenges such as residual leaks, procedural complexity, and the need for standardized protocols persist. Emerging technologies, including personalized device designs and artificial intelligence, hold the potential to optimize outcomes and expand accessibility. The combined procedure represents a transformative strategy in AF management, offering a holistic solution for improving patient outcomes while minimizing risks. JRCD 2024; 4(8): 157–162

 

key word

atrial fibrillation, left atrial appendage closure, catheter ablation, stroke prevention, combined procedure, arrhythmia control, thromboembolic risk, bleeding risk, WATCHMAN device, Amulet device, pulmonary vein isolation, intracardiac echocardiography, 3D printing, personalized medicine, artificial intelligence, real-world evidence

 

References

Calvo N, Salterain N, Arguedas H, Macias A, Esteban A, García de Yébenes M, Gavira JJ, Barba J, García-Bolao I. Combined catheter ablation and left atrial appendage closure as a hybrid procedure for the treatment of atrial fibrillation. Ep Europace. 2015 Oct 1;17(10):1533-40.

Chen M, Sun J, Wang QS, Zhang PP, Li W, Zhang R, Mo BF, Yu YC, Cai X, Yang M, Lian XM. Long-term outcome of combined catheter ablation and left atrial appendage closure in atrial fibrillation patients. International Journal of Cardiology. 2022 Dec 1;368:41-8.

Alipour A, Swaans MJ, van Dijk VF, Balt JC, Post MC, Bosschaert MA, Rensing BJ, Reddy VY, Boersma LV. Ablation for atrial fibrillation combined with left atrial appendage closure. JACC: Clinical Electrophysiology. 2015 Dec;1(6):486-95.

Chen M, Wang ZQ, Wang QS, Sun J, Zhang PP, Feng XF, Li W, Yu Y, Liu B, Mo BF, Zhang R. One-stop strategy for treatment of atrial fibrillation: feasibility and safety of combining catheter ablation and left atrial appendage closure in a single procedure. Chinese medical journal. 2020 Jun 20;133(12):1422-8.

Du X, Chu H, Ye P, He B, Xu H, Jiang S, Lin M, Lin R, Liu J, Wang B, Feng M. Combination of left atrial appendage closure and catheter ablation in a single procedure for patients with atrial fibrillation: multicenter experience. Journal of the Formosan Medical Association. 2019 May 1;118(5):891-7.

SWAANS, Martin J., et al. Ablation for atrial fibrillation in combination with left atrial appendage closure: first results of a feasibility study. Journal of the American Heart Association, 2012, 1.5: e002212.

WATS, Karan, et al. The convergent atrial fibrillation ablation procedure: evolution of a multidisciplinary approach to atrial fibrillation management. Arrhythmia & Electrophysiology Review, 2020, 9.2: 88.

SWAANS, Martin J., et al. Catheter ablation in combination with left atrial appendage closure for atrial fibrillation. JoVE (Journal of Visualized Experiments), 2013, 72: e3818.

HE, Ben, et al. Combination of ablation and left atrial appendage closure as “One‐stop” procedure in the treatment of atrial fibrillation: Current status and future perspective. Pacing and Clinical Electrophysiology, 2021, 44.7: 1259-1266.

PHILLIPS, Karen P.; WALKER, Daniel T.; HUMPHRIES, Julie A. Combined catheter ablation for atrial fibrillation and Watchman® left atrial appendage occlusion procedures: Five-year experience. Journal of arrhythmia, 2016, 32.2: 119-126.

KAWAKAMI, Hiroshi, et al. Cost-effectiveness of combined catheter ablation and left atrial appendage closure for symptomatic atrial fibrillation in patients with high stroke and bleeding risk. American Heart Journal, 2021, 231: 110-120.

WINTGENS, Lisette, et al. Combined atrial fibrillation ablation and left atrial appendage closure: long-term follow-up from a large multicenter registry. EP Europace, 2018, 20.11: 1783-1789.

WANG, An, et al. Efficacy and safety of catheter ablation combined with left atrial appendage closure in the treatment of atrial fibrillation: a systematic review and meta-analysis. Anatolian Journal of Cardiology, 2022, 26.3: 154.

Refbacks

  • There are currently no refbacks.