Investigating Treatment Response and Viral Immunity in Early Rheumatoid Arthritis via Immune Response Profiling
Maytham T. Qasim and Zainab I. Mohammed
Full Text:
Abstract
Rheumatoid arthritis (RA) is an inflammatory illness characterized by chronic inflammation and joint degeneration. Early intervention is crucial for achieving optimal outcomes. This study explores the intricate relationship between treatment response and viral immunity in individuals with early-stage RA using immune response profiling. By examining cytokines produced in response to stimuli such as Cytomegalovirus (CMV) and Epstein-Barr Virus (EBV), researchers identified a specific T-cell immunity profile associated with CMV exposure. This profile significantly impacts clinical outcomes in patients undergoing standard Disease-Modifying Anti-Rheumatic Drug (DMARD) therapy. The findings suggest that alterations in T-cell immunity due to viral persistence, particularly CMV latency, may influence treatment efficacy and disease progression in RA. These insights open opportunities for further research and the development of more effective treatment plans that consider each patient’s unique immunological response profile. The study advances understanding of the immune environment in early RA and has significant implications for tailored therapeutic strategies. Journal of Rare Cardiovascular Diseases 2024; 4(8): 166–173
key word
Treatment, Viral Immunity, Rheumatoid Arthritis, Profiling
References
Buckner, Jane H. “Translational immunology: Applying fundamental
discoveries to human health and autoimmune diseases.” European
Journal of Immunology 53.12 (2023): 2250197.
Comertpay, Betul, and Esra Gov. “Immune cell-specific and common
molecular signatures in rheumatoid arthritis through molecular network
approaches.” Biosystems 234 (2023): 105063.
Coradduzza, Donatella, et al. “Decoding the microbiome’s influence on
rheumatoid arthritis.” Microorganisms 11.9 (2023): 2170.
Floudas, Achilleas, et al. “ACPA status correlates with differential
immune profile in patients with rheumatoid arthritis.” Cells
10.3 (2021): 647.
Garufi, Cristina, et al. “Affecting the effectors: JAK inhibitors
modulation of immune cell numbers and functions in patients with
rheumatoid arthritis.” Expert Review of Clinical Immunology
18.3 (2022): 309-319.
Giannini, Sandro, et al. “The immunologic profile of vitamin D and
its role in different immune-mediated diseases: an expert opinion.”
Nutrients 14.3 (2022): 473.
Jang, Sunhee, Eui-Jong Kwon, and Jennifer Jooha Lee. “Rheumatoid
arthritis: pathogenic roles of diverse immune cells.” International
Journal of Molecular Sciences 23.2 (2022): 905.
Lowe, Katie, et al. “Transcriptomic profiling of programmed cell
death 1 (PD-1) expressing T cells in early rheumatoid arthritis
identifies a decreased CD4+ PD-1+ signature post-treatment.”
Scientific Reports 13.1 (2023): 2847.
Menegatti, Silvia, et al. “Immune response profiling of patients with
spondyloarthritis reveals signalling networks mediating TNF-blocker
function in vivo.” Annals of the Rheumatic Diseases 80.4
(2021): 475-486.
Mulhearn, Ben, Anne Barton, and Sebastien Viatte. “Using the
immunophenotype to predict response to biologic drugs in rheumatoid
arthritis.” Journal of Personalized Medicine 9.4 (2019):
46.
Yamada, Saeko, et al. “Immunomics analysis of rheumatoid arthritis
identified precursor dendritic cells as a key cell subset of treatment
resistance.” Annals of the Rheumatic Diseases 82.6 (2023):
809-819.
Tomkinson, Sophie, et al. “The potential of probiotics as ingestible
adjuvants and immune modulators for antiviral immunity and management of
SARS-CoV-2 infection and COVID-19.” Pathogens 12.7 (2023):
928.
Margiana, Ria, et al. “Functions and therapeutic interventions of
non-coding RNAs associated with TLR signaling pathway in
atherosclerosis.” Cellular Signalling 100 (2022): 110471.
Arif, Anam, et al. “The functions and molecular mechanisms of
Tribbles homolog 3 (TRIB3) implicated in the pathophysiology of cancer.”
International Immunopharmacology 114 (2023): 109581.
Lei, Zimeng, et al. “Detection of abemaciclib, an anti-breast cancer
agent, using a new electrochemical DNA biosensor.” Frontiers in
Chemistry 10 (2022): 980162.
Bashar, Bashar S., et al. “Application of novel Fe3O4/Zn-metal
organic framework magnetic nanostructures as an antimicrobial agent and
magnetic nanocatalyst in the synthesis of heterocyclic compounds.”
Frontiers in Chemistry 10 (2022): 1014731.
Lafta, Holya A., et al. “Tumor-associated macrophages (TAMs) in
cancer resistance; modulation by natural products.” Current Topics
in Medicinal Chemistry 23.12 (2023): 1104-1122.
M Abbas, Mahmoud, et al. “Effects of various irrigation levels and
biochar-based fertilizers on peanut production.” Journal of Nuts
13.4 (2022): 289-300.
Hussein, Hanna Abdulkareem, et al. “Impact of pollution caused by
salmon breeding centers on river water quality.” Caspian Journal of
Environmental Sciences 20.5 (2022): 1039-1045.
Hjazi, Ahmed, et al. “The pathological role of CXC chemokine receptor
type 4 (CXCR4) in colorectal cancer (CRC) progression; special focus on
molecular mechanisms and possible therapeutics.” Pathology-Research
and Practice 248 (2023): 154616.
Alshaibani, Hind Abdulzahra Abdulkadhim, Abdul–Jaleel Aziz Karim
Alqaraghli, and Hadi M. Hamza Al-Mayali. “Diagnostic study of Hyalomma
ticks species parasitic on cows, buffaloes and camels in Dhi Qar
governorate/Iraq.”
Althomali, Raed H., et al. “A novel Pt-free counter electrode based
on MoSe2 for cost effective dye-sensitized solar cells (DSSCs): Effect
of Ni doping.” Journal of Physics and Chemistry of Solids 182
(2023): 111597.
Hjazi, Ahmed, et al. “Unraveling the Impact of 27-Hydroxycholesterol
in autoimmune diseases: exploring promising therapeutic approaches.”
Pathology-Research and Practice (2023): 154737.
Gupta, Jitendra, et al. “Double-edged sword role of miRNA-633 and
miRNA-181 in human cancers.” Pathology-Research and Practice
(2023): 154701.
Sane, Shahryar, et al. “Investigating the effect of pregabalin on
postoperative pain in non-emergency craniotomy.” Clinical Neurology
and Neurosurgery 226 (2023): 107599.
Al-Jassani, Mohammad J., et al. “Isolation and evaluation of
antibacterial agents produced by soil Bacillus sp. and study some of
their immunological parameters.” Revista Electronica de Veterinaria
23.4 (2022): 105-111.
Ze, Langzhun, et al. “The effect of number of nanoparticles on atomic
behavior and aggregation of CuO/water nanofluid flow in microchannels
using molecular dynamics simulation.” Engineering Science and
Technology, an International Journal 47 (2023): 101556.
Al-Dolaimy, F., et al. “Incorporating of cobalt into UiO-67
metal–organic framework for catalysis CO2 transformations: An efficient
bi-functional approach for CO2 insertion and photocatalytic reduction.”
Journal of Inorganic and Organometallic Polymers and Materials
34.2 (2024): 864-873.
Al-Hawary, S. I. S., et al. “Tunneling induced swapping of orbital
angular momentum in a quantum dot molecule.” Laser Physics 33.9
(2023): 096001.
Zaman, Gaffar Sarwar, et al. “Electrochemical determination of
zearalenone in agricultural food samples using a flower like
nanocomposite-modified electrode.” Materials Chemistry and Physics
305 (2023): 127986.
Muzammil, Khursheed, et al. “Methanol extract of Iraqi Kurdistan
Region Daphne mucronata as a potent source of antioxidant,
antimicrobial, and anticancer agents for the synthesis of novel and
bioactive polyvinylpyrrolidone nanofibers.” Frontiers in Chemistry
11 (2023): 1287870.
Farhan, Shireen Hamid, et al. “Exosomal non-coding RNA derived from
mesenchymal stem cells (MSCs) in autoimmune diseases progression and
therapy; an updated review.” Cell Biochemistry and Biophysics
82.4 (2024): 3091-3108.
Qasim, Maytham T., and Zainab I. Mohammed. “The Association of
Helicobacter pylori Infection and Virulence Factors in Gastric Cancer in
Thi-Qar, Iraq.” Asian Pacific Journal of Cancer Biology 9.4
(2024): 541-545.
Zamanian, Mohammad Yasin, et al. “Effects of Resveratrol on
Nonmelanoma Skin Cancer (NMSC): A Comprehensive Review.” Food
Science & Nutrition (2024).
Basem, Ali, et al. “Creep properties of bimetal Al/SiC/Cu composites
fabricated via accumulative roll bonding process.” Journal of
Central South University 31.10 (2024): 3807-3818.
Hsu, Chou-Yi, et al. “MicroRNA-enriched exosome as dazzling dancer
between cancer and immune cells.” Journal of Physiology and
Biochemistry (2024): 1-19.
Lv, Jing, et al. “A comprehensive immunobiology review of IBD: With a
specific glance to Th22 lymphocytes development, biology, function, and
role in IBD.” International Immunopharmacology 137 (2024):
112486.
Ul Hassan Shah, Zameer, et al. “Development of antihyperlipidemic
drug loaded β-CD-based
microparticulate carrier systems: tuning and optimization.”
Polymer-Plastics Technology and Materials 63.11 (2024):
1438-1463.
Hsu, Chou-Yi, et al. “A comprehensive insight into the contribution
of epigenetics in male infertility; focusing on immunological
modifications.” Journal of Reproductive Immunology (2024):
104274.
Patel, Ayyub Ali, et al. “Application of mesenchymal stem cells
derived from the umbilical cord or Wharton’s jelly and their
extracellular vesicles in the treatment of various diseases.” Tissue
and Cell (2024): 102415.
Zamanian, Mohammad Yasin, et al. “Chemopreventive and Anticancer Role
of Resveratrol against non-melanoma skin cancer (NMSC): Focusing on
cellular and molecular mechanisms and biochemistry.” Authorea
Preprints (2024).
Fakhrioliaei, Azadeh, et al. “Potential Role of Nrf2, HER2, and ALDH
in Cancer Stem Cells: A Narrative Review.” The Journal of Membrane
Biology 257.1 (2024): 3-16.
Ramaiah, Pushpamala, et al. “Dietary polyphenols and the risk of
metabolic syndrome: a systematic review and meta-analysis.” BMC
Endocrine Disorders 24.1 (2024): 26.
Al-Hawary, Sulieman Ibraheem Shelash, et al. “Tumor-derived lncRNAs;
Behind-the-scenes mediators that modulate the immune system and play a
role in cancer pathogenesis.” Pathology-Research and Practice
(2024): 155123.
