Journal of Rare Cardiovascular Diseases

ISSN: 2299-3711 (Print) | e-ISSN: 2300-5505 (Online)

Impact of Environmental Pollutants in oil sector workers on some Immunological Parameters: A Critical Analysis

Hasan Mohammed Kadhim1, Nadia Idriss1, Hayder Ali Muhammed2
1University of Sousse, Faculty of Medicine of Sousse, Department of Immunology, Tunisia
2University of Kerbala, faculty of veterinary medicine, department of Immunology, Iraq
Hasan Mohammed Kadhim1, Nadia Idriss1, Hayder Ali Muhammed2
1University of Sousse, Faculty of Medicine of Sousse, Department of Immunology, Tunisia
2University of Kerbala, faculty of veterinary medicine, department of Immunology, Iraq
Corresponding Email: drhayder93@gmail.com
  • Received 30/05/2024
  • Revised 12/10/2024
  • Accepted 30/11/2024

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Abstract

This study investigated the hematological, inflammatory, and genetic responses in workers in the oil industry who were exposed to long-term and short-term environmental contaminants. There were 300 subjects: 100 long-term exposed, 100 short-term exposed, and 100 controls. Blood was collected after overnight fasting for hematological examination, DNA extraction, malondialdehyde (MDA) analysis, glycemia, and interleukin-6 (IL-6) measurement. The TP53 codon 72 (rs1042522) polymorphism was detected by RFLP-PCR. Results indicated a remarkable decrease in hemoglobin level and remarkable increase in erythrocyte sedimentation rate (ESR) in both exposure groups compared to controls. IL-6 levels were also significantly higher in both exposure groups, Arg/Arg genotype of TP53 codon 72 being greater in the long-term exposure group (52%) than in controls (5%). Arg/Arg genotype employees possessed significantly higher levels of IL-6 than Pro/Pro and Arg/Pro genotypes in both groups. The findings support that TP53 Arg/Arg genotype enhances susceptibility to environmental toxins, highlighting the role of genetic factors in interindividual variability to workplace exposures. This study emphasizes the importance of monitoring and screening according to genetic characteristics among exposed workers.

key word
TP53 polymorphism, oil sector worker, MDA, pollution

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