Journal of Rare Cardiovascular Diseases

ISSN: 2299-3711 (Print) | e-ISSN: 2300-5505 (Online)

Impact of environmental pollutants in oil sector workers on some immunological parameters (cardiovascular, genetics, health): A critical analysis

Hasan Mohammed Kadhim1, Nadia Idriss1, Hayder Ali Muhammed2
1University of Sousse, Faculty of Medicine of Sousse, Department of Immunology, Tunisia
2University of Kerbala, faculty of veterinary medicine, department of Immunology, Iraq
Hasan Mohammed Kadhim1, Nadia Idriss1, Hayder Ali Muhammed2
1University of Sousse, Faculty of Medicine of Sousse, Department of Immunology, Tunisia
2University of Kerbala, faculty of veterinary medicine, department of Immunology, Iraq
  • Received 15/12/2024
  • Revised 15/02/2025
  • Accepted 10/04/2025
  • Published 25/05/2025

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Abstract

This study investigated the hematological, inflammatory, and genetic responses in oil sector workers exposed to long-term and short-term environmental toxins. A total of 300 participants were included: 100 with long-term exposure, 100 with short-term exposure, and 100 controls. Blood samples were collected after overnight fasting for hematological assays, DNA extraction, malondialdehyde (MDA) assays, glycemic determination, and interleukin-6 (IL-6) analysis. The TP53 codon 72 (rs1042522) polymorphism was genotyped using RFLP-PCR. Results revealed a significant decrease in hemoglobin concentration and a significant increase in erythrocyte sedimentation rate (ESR) in both exposed groups compared to controls. IL-6 levels were significantly elevated in both exposure groups, with the Arg/Arg genotype of TP53 codon 72 being more prevalent in the long-term exposure group (52%) compared to controls (5%). Workers with the Arg/Arg genotype exhibited significantly higher IL-6 concentrations than those with Pro/Pro or Arg/Pro genotypes in both exposure groups. The findings suggest that the TP53 Arg/Arg genotype may increase susceptibility to environmental toxins, highlighting the role of genetic factors in individual responses to occupational exposures. This study underscores the importance of genetic screening and monitoring in workers exposed to environmental hazards.

key word
TP53 polymorphism, oil sector worker, MDA, pollution, cardiovascular, genetics, health

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Classification of Rare Cardiovascular Diseases anticoagulation atrial fibrillation atrial septal defect cardiac tumor cardiomyopathy computed tomography congenital heart disease echocardiography electrocardiogram electrocardiography heart failure implantable cardioverter‑defibrillator magnetic resonance imaging pregnancy pulmonary arterial hypertension pulmonary hypertension rare cardiovascular disease rare disease right heart catheterization right ventricular failure
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