Journal of Rare Cardiovascular Diseases
ISSN: 2299-3711 (Print)
e-ISSN: 2300-5505 (Online)
Menu
Association of Inflammatory Metabolic Markers in Psoriasis Patient: A Case-Control Study in Karbala City
Zainab Adil Mohammed
Haneen Hadi Abbas
Dhay Abdul Jaleel Kami
Zahraa Emad Hussein
Show More
1
Basic Sciences, College of Dentistry, University of Al-Ameed, Karbala, Iraq
2
Al-Zahraa University for Women, Collage of Health and Medical Technologies Faculty, Department of Radiologic Technology.
Received: 2025-11-11
Revised: 2025-12-09
Accepted: 2025-12-26
Published: 2026-01-01
Full Text
Abstract
B This case-control study was investigated the systemic inflammatory markers in 70 patients with psoriasis against 30 healthy controls in Karbala teaching hospitals, Iraq. Demographic, hematological and immunological parameters were assessed, neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR), systemic immune-inflammation index (SII), systemic inflammation response index (SIRI), interleukin (IL)-17, IL-23 and C-reactive protein (CRP). The patients with psoriasis had a high inflammatory marker that were significantly high in comparison to the controls: SII (632.78 vs 377.2, p=0.032), SIRI (1.042 vs 0.833, p=0.041), and CRP (6.4 mg/L vs 3.8 mg/L, p=0.01). The amount of vitamin B12 was significantly reduced among patients (138.5 pg/mL vs 391.5 pg/mL, p<0.001). A significant correlation was found between SII and CRP (r=0.714, p=0.043) and between SII and IL-23 (r=0.471, p=0.007), and IL-17 demonstrated weaker correlations (SII: r=0.136, p=0.154), The results suggest that SII/SIRI is useful as a biomarker in the context of resource limitations and indicate the existence of possible metabolic comorbidities in the population. The clinical implication of the deficiency of vitamin B12 and IL-23/IL-17 imbalance in Middle East psoriasis patients should be investigated in further studies
Keywords
CRP, Psoriasis, SII, SIRI, IL-17, IL-23
Journal Help
Indexation
User
Keywords
Classification of Rare Cardiovascular Diseases
anticoagulation
atrial fibrillation
atrial septal defect
cardiomyopathy
computed tomography
congenital heart disease
echocardiography
electrocardiogram
electrocardiography
heart failure
implantable cardioverter‑defibrillator
magnetic resonance imaging
pregnancy
pulmonary arterial hypertension
pulmonary hypertension
rare cardiovascular disease
rare disease
right heart catheterization
right ventricular failure
Instruction for authors
Submit an article